Document 0868
 DOCN  M9620868
 TI    Clinical isolates of Mycobacterium simiae in San Antonio, Texas. An
       11-yr review.
 DT    9602
 AU    Valero G; Peters J; Jorgensen JH; Graybill JR; Department of Infectious
       Diseases, University of Texas Health; Science Center at San Antonio
       78284-7870, USA.
 SO    Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1555-7. Unique
       Identifier : AIDSLINE MED/96048813
 AB    During a period of 11 yr (1983-1993) 137 clinical isolates of
       Mycobacterium simiae obtained from 75 patients were identified in a
       University hospital in San Antonio, Texas. One hundred twenty-eight
       isolates (93%) were from a pulmonary source, four (3%) from blood, and
       five from other sites including skin, urine, lymph node, bone marrow,
       and brain. Of 62 evaluable patients, six (10%) had definite infection,
       nine (14%) had probable disease, and 48 (76%) were thought to be
       colonized. During the last 2 yr of the study (1992 and 1993), M. simiae
       became the second most frequently isolated nontuberculous mycobacterium
       at this institution surpassed only by Mycobacterium avium complex. There
       are limited data about effective treatment for this multidrug-resistant
       organism. New macrolides, quinolones, ethambutol, clofazimine, and
       aminoglycosides are promising therapeutic agents.
 DE    Adult  AIDS-Related Opportunistic Infections/MICROBIOLOGY  Child,
       Preschool  Drug Resistance, Microbial  Drug Resistance, Multiple  Female
       Human  HIV-1  Male  Microbial Sensitivity Tests  Middle Age
       Mycobacterium/DRUG EFFECTS/*ISOLATION & PURIF  Mycobacterium
       Infections/MICROBIOLOGY  Retrospective Studies  Texas  JOURNAL ARTICLE

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