Document 0876 DOCN M9620876 TI T cell-rich B cell lymphoma bearing Epstein-Barr virus in tumor cells: a case of IBL-T-like lesion following Lennert's lesion. DT 9602 AU Wakatsuki S; Yumoto N; Takagi T; Kurosu K; Sakai C; Tamayama C; Komatsu T; Matsuzaki O; Mikata A; Division of Surgical Pathology, Chiba Cancer Center Hospital,; Japan. SO Pathol Int. 1995 Jun;45(6):457-62. Unique Identifier : AIDSLINE MED/96086452 AB A case of T cell-rich B cell lymphoma (TCRBCL) with Epstein-Barr virus (EBV) infection in tumor cells is reported. A 50 year old male developed right cervical lymph node swelling in July 1988. Initial biopsy in April 1989 demonstrated many scattered Hodgkinoid atypical cells with Lennert's lesion. After partial remission following chemotherapy, the lymph nodes enlarged again, and a second biopsy in February 1991 showed an IBL-T-like lesion. Only a small number of Hodgkinoid atypical cells were still observed. After apparently, complete remission, the lesion soon recurred and the patient died in November 1992. Immunohistochemically the Hodgkinoid cells were positive for L26, but negative for LN2, LN3, UCHL-1, MT1, lysozyme, Ber-H2 and Leu-M1. Reactivity for immunoglobulins showed false-positive because of polyclonal staining. IgH monoclonality was detected by the polymerase chain reaction method in the first biopsied specimen, and by Southern blotting in the second biopsied snap-frozen specimen. Monoclonal TCR beta rearrangement was not detected. The Hodgkinoid atypical cells were positive for EBV-encoding RNA by in situ hybridization, and LMP-1 by immunostaining. Occasionally, EBV-bearing immunoblastic, medium sized, or small lymphocytic cells were also observed. This case indicates the possibility that EBV is related to the pathogenesis of TCRBCL. DE Blotting, Southern Case Report *Herpesvirus 4, Human/GENETICS Human Immunoblastic Lymphadenopathy/*PATHOLOGY/VIROLOGY In Situ Hybridization Lymphoma, B-Cell/*PATHOLOGY/VIROLOGY Male Middle Age Polymerase Chain Reaction RNA, Viral/ANALYSIS Tumor Virus Infections/*PATHOLOGY/VIROLOGY Viral Matrix Proteins/ANALYSIS JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).