Document 0887
 DOCN  M9620887
 TI    Structure-activity correlationship and strain specificity of
       polyoxometalates in anti-human immunodeficiency virus activity.
 DT    9602
 AU    Inouye Y; Fujimoto Y; Sugiyama M; Yoshida T; Yamase T; Institute of
       Pharmaceutical Sciences, Hiroshima University School; of Medicine,
       Japan.
 SO    Biol Pharm Bull. 1995 Jul;18(7):996-1000. Unique Identifier : AIDSLINE
       MED/96080767
 AB    The anti-human immunodeficiency virus (HIV) activity of polyoxometalates
       of representative structural families, such as Keggin, lacunary Keggin,
       trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson
       sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIB
       and HIV-1SF-2H). The compounds were preferably selected to cover both
       polyoxotungstates and polyoxomolybdates in each structural family. In
       general, polyoxotungstates of Keggin, lacunary Keggin, trivacant Keggin,
       Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures
       showed anti-HIV-1HTLVIIIB activity, whereas most compounds not included
       in these structural categories were inactive. Among the compounds with a
       potent anti-HIV-1HTLV-IIIB activity, those of Keggin and its closely
       related structural families (lacunary Keggin, trivacant Keggin and
       Keggin sandwich) inhibited the cytopathogenicity and syncytium formation
       caused by HIV-1SF-2 to a much higher extent compared with
       HIV-1HTLV-IIIB-related ones. The difference between the spectra of
       anti-HIV-1HTLV-IIIB activity and the specificity for HIV-1SF-2H might
       result from differential structural requirements in these functions.
 DE    Antiviral Agents/*PHARMACOLOGY  Cells, Cultured  Comparative Study
       Cytopathogenic Effect, Viral/DRUG EFFECTS  Fluorescent Antibody
       Technique, Direct  Human  HIV-1/*DRUG EFFECTS/METABOLISM
       Molybdenum/*PHARMACOLOGY  Species Specificity  Structure-Activity
       Relationship  Tungsten Compounds/*PHARMACOLOGY  Vanadium
       Compounds/*PHARMACOLOGY  Viral Proteins/BIOSYNTHESIS  JOURNAL ARTICLE

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