Document 0901
 DOCN  M9620901
 TI    Contribution of alpha interferon (alpha IFN) to HIV-induced
       immunosuppression.
 DT    9602
 AU    Lachgar A; Bizzini B; Laboratoire de Physiologie Cellulaire, Universite
       Pierre et; Marie Curie, Paris, France.
 SO    Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):431-7. Unique Identifier
       : AIDSLINE MED/96059405
 AB    In the present investigation we have shown that PBLs taken from
       HIV-positive patients suppressed T-cell proliferation when cultured for
       at least 12 days. When infected In vitro with HIV-1, these cells become
       suppressive after 6 days. PBLs collected from seronegative individuals
       turned out to be non-suppressive even after prolonged culturing.
       However, when infected in vitro with HIV they were found to be
       cytostatic also after 6 days. This anti-immune activity, related to HIV
       infection, is mediated, at least in part, by alpha IFN, since about 50%
       of this HIV associated activity could be quenched by alpha IFN
       antibodies. We also showed that this T-cell cytostasis is associated
       with CD8+ cells. In view of a possible use of suppressive cells for
       T-cell vaccination, we verified that such cellular functions were
       abolished by aldehyde treatment.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Aldehydes/PHARMACOLOGY
       Comparative Study  CD8-Positive T-Lymphocytes/IMMUNOLOGY/METABOLISM
       Female  Human  HIV-1/IMMUNOLOGY  Immune Sera/PHARMACOLOGY  *Immune
       Tolerance  In Vitro  Interferon-alpha/BIOSYNTHESIS/*IMMUNOLOGY
       Lymphocyte Transformation  Lymphocytes/DRUG EFFECTS/*IMMUNOLOGY/VIROLOGY
       Male  T-Lymphocytes/IMMUNOLOGY  Time Factors  JOURNAL ARTICLE

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