Document 0923
 DOCN  M9620923
 TI    Decreasing HIV-1 seroprevalence in young adults in a rural Ugandan
       cohort.
 DT    9602
 AU    Mulder D; Nunn A; Kamali A; Kengeya-Kayondo J; Medical Research Council
       Programme on AIDS in Uganda, Entebbe.
 SO    BMJ. 1995 Sep 30;311(7009):833-6. Unique Identifier : AIDSLINE
       MED/96066563
 AB    OBJECTIVE--To assess the trend in HIV-1 seroprevalence in an adult
       population in Uganda. DESIGN--An observational cohort study with four
       year follow up. SETTING--A cluster of 15 villages in rural Uganda.
       SUBJECTS--All residents of the 15 villages--about 10,000 people. MAIN
       OUTCOME MEASURE--Prevalence of HIV-1 infection as assessed by enzyme
       immunoassay. RESULTS--During the five year period the overall
       standardised seroprevalence of HIV-1 showed little change; 8.2% in 1990,
       7.6% in 1994. Among males aged 13-24 years the prevalence decreased from
       3.4% to 1.0% (P for trend < 0.001); among females of the same age the
       corresponding values were 9.9% and 7.3%. The decrease was greatest in
       males aged 20-24 years and females aged 13-19 years. CONCLUSION--This is
       the first report of a decline in HIV-1 prevalence among young adults in
       a general population in sub-Saharan Africa with high overall HIV-1
       prevalence. It is too early to conclude that the epidemic in this
       population is in decline, but the results of this study should be reason
       for some cautious optimism and encourage the vigorous pursuit of AIDS
       control measures.
 DE    Adolescence  Adult  Cohort Studies  Female  Follow-Up Studies  Human
       HIV Infections/*EPIDEMIOLOGY  HIV Seroprevalence/TRENDS  *HIV-1  Male
       Prevalence  *Rural Health  Sex Factors  Support, Non-U.S. Gov't
       Uganda/EPIDEMIOLOGY  JOURNAL ARTICLE

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