Document 1000 DOCN M9621000 TI Inducible nitric oxide synthase in the central nervous system. DT 9602 AU Sparrow JR; Department of Ophthalmology, Cornell University Medical College,; New York, NY 10021, USA. SO J Mol Neurosci. 1994-95;5(4):219-29. Unique Identifier : AIDSLINE MED/96101969 AB There is an accumulation of evidence indicating that induction of the calcium-independent isoform of nitric oxide synthase (iNOS) in glial cells can contribute to nitric oxide-mediated neural-cell damage. Elucidation of iNOS inducing signals and mechanisms regulating its augmentation and suppression may have implications for our understanding of basic processes underlying some forms of central nervous system disease. DE Animal Astrocytes/ENZYMOLOGY AIDS Dementia Complex/ENZYMOLOGY/PATHOLOGY Brain Diseases/ENZYMOLOGY/PATHOLOGY Cell Death Central Nervous System/*ENZYMOLOGY Encephalitis/ENZYMOLOGY/PATHOLOGY Enzyme Induction Human Isoenzymes/BIOSYNTHESIS/PHYSIOLOGY Mice Nerve Tissue Proteins/BIOSYNTHESIS/*PHYSIOLOGY Neuroglia/ENZYMOLOGY Neurons/PATHOLOGY Nitric Oxide/METABOLISM Nitric-Oxide Synthase/BIOSYNTHESIS/*PHYSIOLOGY Rats JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).