Document 1001
 DOCN  M9621001
 TI    [Idiopathic CD4+ lymphocytopenia: a case report]
 DT    9602
 AU    Frassanito MA; Iodice G; Rizzi R; Dammacco F; Dipartimento di Scienze
       Biomediche ed Oncologia Umana,; Universita degli Studi di Bari.
 SO    Ann Ital Med Int. 1995 Jul-Sep;10(3):188-92. Unique Identifier :
       AIDSLINE MED/96045855
 AB    We present the case of a 47-year-old patient who was seen for recurrent
       opportunistic infections. Immunophenotypic analyses disclosed severe
       reduction of CD4+ T cells. Repeated Elisa, Western blot and polymerase
       chain reaction tests for HIV were negative. The low CD4+ T lymphocyte
       count unaccompanied by increased CD8+ T lymphocytes and
       hypergammaglobulinemia, along with negativity for HIV infection,
       suggested the diagnosis of idiopathic CD4+ lymphocytopenia (ICL). The
       patient's clinical manifestations and laboratory results conformed with
       the case definition of ICL established in 1992 by the Centers for
       Disease Control of Atlanta, i.e., CD4+ T cells < 300/mm3 on two
       occasions and no evidence of HIV infection. In vitro analyses evidenced
       depressed lymphoproliferative responses to mitogens such as concanavalin
       A and pokeweed mitogen, while the expression of Fas antigen on
       peripheral lymphocytes and the percentage of apoptotic cells after
       propidium iodide staining were increased. Since in vitro concanavalin A
       stimulation inhibits T cell proliferation and induces apoptosis, these
       results suggest that the patient's lymphocytes are susceptible, in vivo,
       to an apoptotic signal.
 DE    Apoptosis  Bronchopneumonia/BLOOD/DIAGNOSIS  Candidiasis,
       Oral/BLOOD/DIAGNOSIS  Case Report  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/PATHOLOGY  English Abstract  Human  Male  Middle Age
       Opportunistic Infections/BLOOD/DIAGNOSIS  Recurrence  Support, Non-U.S.
       Gov't  T-Lymphocytopenia, Idiopathic CD4-Positive/BLOOD/*DIAGNOSIS
       JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

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