Document 1014
 DOCN  M9621014
 TI    Defective natural killer cell cytotoxic activity in feline
       immunodeficiency virus-infected cats.
 DT    9602
 AU    Zaccaro L; Falcone ML; Silva S; Bigalli L; Cecchettini A; Giorgi F;
       Malvaldi G; Bendinelli M; Centro Retrovirus, Universita di Pisa, Italy.
 SO    AIDS Res Hum Retroviruses. 1995 Jun;11(6):747-52. Unique Identifier :
       AIDSLINE MED/96078236
 AB    Flow cytometry has been employed to study NK cell cytotoxic activity in
       cats infected with feline immunodeficiency virus. The results show that
       animals infected for 12 months or more have decreased levels of NK cell
       cytotoxic activity in their blood. The impairment could not be overcome
       by in vitro treatment of effector cells with interleukin 2. Additional
       results suggest that the NK cells of infected cats are defective, in
       that they are still able to bind to target cells but have a reduced
       ability to kill them.
 DE    Animal  Cats  Cytotoxicity Tests, Immunologic/METHODS  *Cytotoxicity,
       Immunologic  CD4-CD8 Ratio  Immunodeficiency Virus, Feline/*IMMUNOLOGY
       Interleukin-2/PHARMACOLOGY  Killer Cells, Natural/*IMMUNOLOGY
       Lentivirus Infections/*IMMUNOLOGY  Leukocytes, Mononuclear/DRUG EFFECTS
       Matched-Pair Analysis  Specific Pathogen-Free Organisms  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

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