Document 1084
 DOCN  M9621084
 TI    Lack of requirement for CD8+ cells in recovery from and resistance to
       experimental autoimmune encephalomyelitis.
 DT    9602
 AU    Lohse AW; Schwerdt A; Herkel J; Spahn T; Meyer zum Buschenfelde KH;
       Department of Medicine, Johannes Gutenberg-University, Mainz,; Germany.
 SO    J Autoimmun. 1995 Jun;8(3):395-404. Unique Identifier : AIDSLINE
       MED/96082299
 AB    Experimental autoimmune encephalomyelitis (EAE) is a model of T-cell
       mediated autoimmune disease. Active disease is mediated by myelin basic
       protein specific CD4+ T-cells, whose adoptive transfer can also induce
       passive disease. In the Lewis rat EAE is a transient disease inducing
       lasting resistance to rechallenge. The mechanisms of recovery and
       resistance are poorly understood. CD8+ suppressor T-cells have mostly
       been thought to be central, especially in resistance to reinduction of
       the disease. In this study we showed by complete depletion of CD8+ cells
       that this subset does not influence either recovery or resistance to EAE
       in the Lewis rat. This was further confirmed by depleting CD8+ cells
       only after recovery from acute EAE. Such depletion did not diminish the
       effective resistance to rechallenge. Recovery from and resistance to EAE
       appear not to require the presence of CD8+ cells.
 DE    Animal  Antibodies, Monoclonal/IMMUNOLOGY/THERAPEUTIC USE  CD4-CD8 Ratio
       CD8-Positive T-Lymphocytes/*IMMUNOLOGY  Encephalomyelitis,
       Allergic/*IMMUNOLOGY/PREVENTION & CONTROL/  THERAPY  Female  Immunity,
       Natural  Lymphocyte Depletion  Rats  Rats, Inbred Lew  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

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