Document 0915
 DOCN  M9650915
 TI    Clinico-pathological study of cytomegalovirus (CMV) in AIDS autopsies:
       under-recognition of CMV pneumonitis and CMV adrenalitis.
 DT    9505
 AU    Dore GJ; Marriott DJ; Duflou JA; St Vincent's Hospital, Sydney, NSW.
 SO    Aust N Z J Med. 1995 Oct;25(5):503-6. Unique Identifier : AIDSLINE
       MED/96154418
 AB    BACKGROUND: Cytomegalovirus (CMV) is a common cause of morbidity in
       human immunodeficiency virus (HIV) infected patients, predominantly when
       severe immunosuppression has occurred. Although CMV infection of the
       retina and gastrointestinal tract is well recognised as causing
       substantial morbidity, the significance of infection at other sites, in
       particular the lungs and adrenal glands is unclear. AIMS: To assess the
       extent of CMV infection in postmortem examinations performed on
       HIV-infected patients. To estimate the degree of concordance between
       clinical and postmortem findings and the effect of prior diagnosis
       and/or treatment of CMV infection. METHODS: The postmortem examination
       findings and clinical records of 25 consecutive HIV-infected patients
       who underwent a complete autopsy were examined. RESULTS: CMV infection
       was demonstrated in 19 patients (76%) at postmortem examination, with
       the most common sites of infection being the adrenal glands (56%) and
       lungs (44%). Concordance between clinical diagnosis of CMV infection and
       postmortem findings was low with only five of 19 patients (26%) having
       an antemortem diagnosis. No patient with CMV infection of the lungs or
       adrenal glands had a clinical diagnosis made, despite four patients
       having florid CMV pneumonitis at postmortem examination; in three the
       probable cause of death. CONCLUSION: CMV infection is a common
       postmortem finding in HIV-infected patients but the concordance between
       clinical diagnosis and autopsy findings is low. CMV appears to be a
       significant pathogen in HIV-related respiratory disease.
 DE    Adrenal Gland Diseases/COMPLICATIONS/*VIROLOGY  Adult  Autopsy
       AIDS-Related Opportunistic Infections/*VIROLOGY  Cytomegalovirus
       Infections/*COMPLICATIONS  Human  Male  Middle Age  Pneumonia,
       Viral/COMPLICATIONS/*VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).