Document 0941
 DOCN  M9650941
 TI    Characterization of humoral and cellular immunity in the central nervous
       system of HAM/TSP.
 DT    9505
 AU    Matsui M; Nagumo F; Tadano J; Kuroda Y; Department of Internal Medicine,
       Saga Medical School, Japan.
 SO    J Neurol Sci. 1995 Jun;130(2):183-9. Unique Identifier : AIDSLINE
       MED/96172597
 AB    In HTLV-I-associated myelopathy or tropical spastic paraparesis
       (HAM/TSP) immunopathological processes in the central nervous system
       (CNS) have not been clarified. We compared the humoral and cellular
       immunity within the CNS and in the systemic circulation of 24 patients
       with HAM/TSP (8 men and 16 women) to 6 asymptomatic HTLV-I carriers, 7
       patients with active multiple sclerosis, 6 patients with acute viral
       encephalitis, and 39 patients with other non-inflammatory neurological
       diseases. Significant differences were observed between the HAM/TSP
       patients and one or more of the control groups: HAM/TSP cerebrospinal
       fluids (CSF) exhibited higher levels of IgG, IgG index, de novo IgG
       synthesis rate, and beta 2-microglobulin, and also a predominance of
       CD8+ cells that expressed CD11a and CD45RO but lacked CD28 antigens.
       Results in the 6 patients with acute viral encephalitis suggested that
       the CD8+ population in the CSF which is positive for CD28 and CD45RO is
       important for the elimination of virus from infected CNS tissues.
       Therefore, potentially cytotoxic T cells of a unique
       CD8+CD11a+CD45RO+CD28- phenotype may play a key role in the CNS
       pathogenesis of HAM/TSP.
 DE    Adult  Aged  Antibody Formation/*PHYSIOLOGY  Central Nervous
       System/*IMMUNOLOGY  Female  Human  IgG/BIOSYNTHESIS  Immunity,
       Cellular/*PHYSIOLOGY  Lymphocyte Subsets/IMMUNOLOGY  Male  Middle Age
       Multiple Sclerosis/CEREBROSPINAL FLUID/IMMUNOLOGY  Nervous System
       Diseases/CEREBROSPINAL FLUID/IMMUNOLOGY  Paraparesis, Tropical
       Spastic/CEREBROSPINAL FLUID/*IMMUNOLOGY  Phenotype  Support, Non-U.S.
       Gov't  T-Lymphocytes, Cytotoxic/IMMUNOLOGY  CLINICAL TRIAL  JOURNAL
       ARTICLE

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