Document 0942
 DOCN  M9650942
 TI    [A factor to enhance HIV replication in serum bearing a resemblance to
       membranes of Acholeplasma laidlawii]
 DT    9505
 AU    Hayashi R; Department of Bacteriology, Obstetrics & Gynecology, Kurume;
       University School of Medicine.
 SO    Kansenshogaku Zasshi. 1995 Dec;69(12):1389-95. Unique Identifier :
       AIDSLINE MED/96155225
 AB    We found a substance A in human serum by ELISA method, using anti-A
       antibody. The substance A was obtained from the membranes of A.
       laidlawii and this enhanced HIV replication. This substance in human
       serum was detected in the chloroform phase of the Bligh-Dyer method. Rf
       value in thin layer chromatography was 0.28. This substance clearly
       showed enhancement of HIV replication as well as the activity of the
       membranes of A. laidlawii, but did not induce TNF production.
       Furthermore, the activity which enhances HIV replication in human serum
       was reduced by anti-A antibody. These results suggest that the substance
       derives from human serum which possesses a similar active site as those
       of substance derived from the membrane of A. laidlawii.
 DE    *Acholeplasma laidlawii  Bacterial Outer Membrane Proteins/*PHARMACOLOGY
       English Abstract  Enzyme-Linked Immunosorbent Assay  Human
       HIV/*PHYSIOLOGY  Immune Sera/IMMUNOLOGY  Virus Replication/*DRUG EFFECTS
       JOURNAL ARTICLE

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