Document 0965
 DOCN  M9650965
 TI    PdbAlign, PdbDist and DistAlign: tools to aid in relating sequence
       variability to structure.
 DT    9505
 AU    Sayle R; Saqi M; Weir M; Lyall A; Department of Biomolecular Structure,
       Glaxo Medicines Research; Centre, Stevenage, Herts, UK.
 SO    Comput Appl Biosci. 1995 Oct;11(5):571-3. Unique Identifier : AIDSLINE
       MED/96163640
 AB    Many sequence analysis problems involve consideration of a multiple
       sequence alignment where the 3-dimensional structure of one (or more) of
       the aligned sequences is known. In such cases, it is useful to map the
       sequence variability onto the atomic co-ordinates of known structure. If
       the structure also includes a bound ligand (or the location of the
       active site is known), each column position in the multiple sequence
       alignment may be annotated with its 'distance' from the binding site.
       These annotations, together with a measure of sequence variability,
       provide additional insights into drug specificity, for example among
       viral mutants. This paper describes several useful programs that
       automate this analysis.
 DE    Amino Acid Sequence  Binding Sites/GENETICS  HIV
       Protease/CHEMISTRY/GENETICS  Models, Molecular  Molecular Sequence Data
       Molecular Structure  Protein Conformation  Proteins/CHEMISTRY/*GENETICS
       Sequence Alignment/*METHODS/STATISTICS & NUMER DATA  Sequence Homology,
       Amino Acid  *Software  *Variation (Genetics)  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).