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CD-ROM Today (UK) (Spanish) 15
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0215
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02159.txt
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1994-01-17
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$Unique_ID{BRK02159}
$Pretitle{}
$Title{Cushing's Disease}
$Subject{Cushing Cushing's Disease neurosurgery pituitary gland sphenoid bone
hormones thyroid ovaries blood pressure adrenal adrenocorticotropic
cortisol rounded face skin neck abdomen metabolism sugar osteoporosis
infection mental disturbances irradiation tumor}
$Volume{}
$Log{
Location and Function of the Endocrine Glands*0002901.scf}
Copyright (c) 1993 Tribune Media Services, Inc.
Cushing's Disease
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QUESTION: Although I received a rather long and complete explanation of the
Cushing's Illness from my own doctor, I think he went a bit faster than my
mind could hold, and so I still don't know what it means. Yet I know it is
serious, and hope you can explain where it comes from. Then maybe I can
understand why I look the way I do.
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ANSWER: One of the medical geniuses of the last century was Dr. Harvey
Cushing, of Cleveland Ohio, and a professor of surgery at Johns Hopkins and
Harvard University. His work in neurosurgery was outstanding, and he provided
medical science with a great deal of knowledge about the pituitary gland. The
pituitary gland is a very small, but extremely important organ that sits under
the center of the brain in a small protective pocket of bone in the sphenoid
bone. It has two lobes, and each produces a number of hormones that act both
directly and indirectly on other body functions. Thus it acts on the thyroid,
the ovaries, helps control blood pressure, and most important for you,
secretes a hormone that acts on the adrenal gland. Stick with me now, for
here's where it gets a bit complicated. The hormone is known as
adrenocorticotropic hormone (or ACTH). It stimulates the adrenal gland to
secrete cortisol, a cortisone-like hormone that is essential to the body
functions. When too much ACTH is produced, as in the case of a hormone
producing tumor of the pituitary, too much cortisol is released into the body,
producing the condition known as Cushing's Disease. This results in a rounded
"moon" like face, the development of prominent fat pads at the back of the
neck (named "buffalo humps"), thin pale skin, and long purple lines (striae)
across the abdomen. Problems with the metabolism of sugar, osteoporosis,
reduced resistance to infection and even mental disturbances are common. The
solution lies in attacking the tumor, either by removing it surgically or
using high voltage irradiation to kill the cells. The surgery is demanding
and is only performed in specialized centers. Now with this new explanation
(which I hope helps you to understand), return to your doctor for additional
explanations. This is indeed a complicated situation, so take all the time
you need to get answers you understand.
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The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician. Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.