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Cancer - Principles & Practice of Oncology
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Oncology.iso
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CHAP35
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T3_8.GIF
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1999-06-07
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OCR:
Series Agent Dose Patients CR PR Endpoint Or Comment PROG ESTOGENS Reifenstein, Jr 252 HPC g/w 314 (30.2% Median survival 20 months Geisler255 MA 40- -80-160 mg/d (14.2 42.8- Bonte et al.254 MPA g/w 106 (53%) Mean survival 10 months Podratz al 150 MPA, HPC 155 (11 .2%) Retrospective 1968 1980 Quinn 955 MPA 400 mg/d 22 (9% Receptor -positive 2/9 responses Thigpen et al.256 MPA 200 mg/d 138 (26%) vs MPA 1000 mg/d 140 18% Lenz er al 15 MA 800 mg/d 50 (26%) Median survival 7.6 months TAMOXIFEN Ouinn Campbeise TAM 40 mg/d 20% Edmondson TAM 20 mg/d (21%) No activity if refractory to progestogens Swenerton TAM 20 mg/d 35 (23%) Rendina et TAM 40 mgid 4P (36% Haid et al 25 TAM 20 mg/d 26 31%) Thigpen 258 TAM 20 mg/d 63 281) No activity with prior therapy TAMOXIFEN PLUS PROGESTOGENS Pandya et al 259 ...