ocr: LOW-RISK (SINGLE AGENTS) Methotrexale*: 30-50 mg/m IM weekly; 0.4. mg/kg IM or IV daily X5 days (repeat in 2 wk); or 1 mg/kg IM or IV on days 1, 3,5,and 7 (repeat in 2 wk) plus folinic acid (leucovorin), 0.1 mg/kg or IV on days 2,4,6,and 8 Dactanomycin: 1.25 mg/m IV (repeat in 2 wk), or 10 ug/kg (up to 0.5 mg) IV daily X 5 d (repeat in 2 wk) INTERMEDIATE- OR HIGH-RISK (DRUG COMBINATIONS) EMA-CO consists ofa alternating cycles of EMA (days 1 and 2) and CO (day 8) Day 1 EMA: etoposide, 100 mg/m? IV; and dactinomycm, 0.5 mg IV; and nethotrexate, 1001 mg IV push followed by 200 mg/m? 12-h IV Day 2 ...
