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OCR: Countr Reference Randomization Patient Result Commen Hong Kong Cisplatin 120 mg/m versus 60 mg/m Increased Nonuniform staging and survival for low statistical power high dose United States 192 001 mg/m cisplatin plus 1000 mg/m2 485 No difference Dose intensity ot cyclophosphamide x cycles versus 50 in survival cisplatin doubled mg/m cisplatin plus 500 mg/m cyclophosphamide x 8 cycles Italy 193 75 mg/m cisplatin every wk cycles 295 No difference Dose intensity of versus 50 weekly cycles in survival cisplatin doubled Italy 194 100 mg/m or 50 mg/m cisplatin plus 145 No difference Three drug dose- -intense epidoxorubicin 60 mg/m and in response combination leading cyclophosphamide 600 mg/m or survival more toxicity but no survival benefit Scotiand 159 100 mg/m cisplatin plus 750 mg/m 165 Impro ...