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Cancer - Principles & Practice of Oncology
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CHAP37
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F1_3.CAP
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1999-06-07
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FIGURE 37.1-3. Flow diagram of proven and postulated events in thyroid
follicular cell tumorigenesis. Mutations in the RAS oncogene are
believed to be early events in the genesis of follicular neoplasms.
Activation of the RET and TRK receptor tyrosine kinases is specific to
papillary thyroid carcinomas. The association of mutations in the p53
tumor suppressor gene with undifferentiated thyroid tumors suggests
that mutations in TP53 are a critical event in the progression of
follicular carcinoma to anaplastic carcinoma.