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/ Cancer - Principles & Practice of Oncology / Oncology.iso / PPO / CHAP37 / T2_8.GIF

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Graphics Interchange Format  |  1999-06-07  |  86KB  |  748x364  |  8-bit (240 colors)

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OCR: Familial Sporadic Non MEN MEN 76 MEN 9R Age ar diagnosis ( 94 97 15-20 Gender Associated diseases None None Pheochromocytoma Pheochromocy 'toma (2 Hyper parathyroidism 9 Marfanoid body habitus (3) Oral & eye Mucosal neuromas (4) Gastrointestinal ganglioneur romas Disease extent Unilateral Bilateral Bilateral Bilateral Lymph nodes 40% -50% 10% 20% 149 38% involved diagnosis Distant metastases ar 12 0% %830 20% diagnosis Cured of MTC 14% -30% 70%- -80% 56% 100% 0 Dead due t0 MTC 30% 360 0 17% 50% Mutations in RET on Met 918 >Thr (33%) Mutations m cysteine Mutations in cysteines in Met 918-Thr chronosome Glu 768- Asp extracellular domain extracellular domain neai membrane near membrane Discase Mutation chromosome extraceiuar extraceliutar

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