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/ Cancer - Principles & Practice of Oncology / Oncology.iso / PPO / CHAP37 / T7_1.GIF

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Graphics Interchange Format  |  1999-06-07  |  79KB  |  748x333  |  8-bit (240 colors)

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OCR: Characteristics MEN MEN 20 MEN 21 FMTC Chromosome 12-19 Pericentromeric Pericentromeric 10 Pericentromeric Genetic defect Unknown RET mutation RET mutation RET mutation MTC Bilatcral Bilateral Bilateral Pheochromocytoma Nc bilateral bilateral No Parathyroid disease Hyperplasia Hyperplasia No Phenotype Bony abnormalities, No mucosal neuromas, marf fanoid habitus, bumpy lips Mode pf Autosomal dominant Autosomal dominant Autosomal dominant Autosomal dominant inheritance Course of MTC No MTC Variable, frequently More virulent Most indolent indolent Pancreatic Yes No endocrine tumors PPoma 80% 100% Gastrinoma 50% 20% GRFoma, VIPoma (uncommon) Pheoch romocytoma Hyper plasia Hyperp Insuiinoma

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