ocr: Increased toxicity is encountered at higher WBC. Many therapists use hydroxyurea (1-5gPO qd) initially to reduce the WBC to less than 10-20 X 10uL. IFN-ais then commenced and the hydroxyurea 1S tapered gradually. Initiate IFN-a at a lower dose initially (3 million units SC qd for 3-7 days, then increase to5-6million units SCqd)toi induce castyphylaxis to. IFN-related side effects. Give IFN-a at bedtime and premedicate with acetaminophen. Older patients tolerate IFN-a less well than younger patients. Fatigue, depression, and insomnia (frequently encountered together) 1S treatable with 12.5-50 m ...
