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- TABLE 45.4-10. Dosage Schedules for the M2, VMCP-VBAP, ABCM, and VAD
- Regimens
-
- P, prednisone; D, dexamethasone.
- *As currently used, the M2 protocol is usually repeated at 4- or
- 5-week intervals. The VMCP-VBAP program repeats courses of
- chemotherapy in 21-day cycles using either a direct alternation of the
- two regimens or a syncopated alternation wherein VMCP is used for
- three cycles followed by VBAP for three cycles with similar
- therapeutic results by either of these schedules. Currently, an
- every-3-week alternation is used. The MRC has used an almost identical
- schedule to VMCP-VBAP in their alternating program, except that
- vincristine and prednisone have been deleted. Alternations are also at
- 3-week intervals in the MRC's ABCM program. The VAD regimen is
- repeated every 35 days, and patients generally receive an
- antiinfective agent (e.g., sulfa trimethoprim or ciprofloxacin) during
- the period of blood count nadir (e.g., days 10 to 20), as well as an
- H(2)-blocking agent.
-