ocr: Responsive patients who satisfy all of the following criteria are consid- ered to have achieved definite objective mprovement: A: sustained decrease in the synthesis index of serum M protein to 25%, or less, of the pretreatment value on atleast two neasurements separated by 4 wk. For IgAand IgG3 M-proteins, the synthetici index 1S the same as the serum concentration. For IgG M-proteins of sub- classes 1, 2, and 4, the synthetic index must be estimated using the nomogram shown in Figure 47-6. As sustained decrease in 24-h urine globulin to 10%, or less, of the pretreatment value, and to less th ...
