ocr: Route Dose and Schedule CYCLOPHOSPHAMIDE IV 1000 mg/m? (27 mg/kg)q3wk Oral 250 mg/m'idx4dq3 wk MELPHALAN IV 16 mg/m q2 - wk X 4 then 94 wk Reduce initial dosing by 50% if serum creatinine > 2 mg/ dL (BUN > 30 mg/dL) Oral 8r mg/m? 93 wk or 9 mg/m? 94wk (Because of varying bioavailability of oral melphalan, the dose must be increased to induce hematologic toxicity or significant underdosing may occur.) CARMUSTINE (BCNU) IV 100-150 mg/m 94-6wk LOMUSTINE (CCNU) Oral 130 mg/m-q4-6wk
