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Cancer - Principles & Practice of Oncology
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F6.CAP
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1999-06-07
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FIGURE 60-6. Comparative analysis of vaccine efficacies of a poorly
immunogenic murine tumor transduced with different cytokine genes.
Syngeneic C57BL/6 mice were vaccinated subcutaneously with 5 x 10**5
irradiated (3500 rad) B16 melanoma cells transduced with eight
different cytokine genes using the MFG retroviral vector. Animals were
challenged 14 days later with 1 x 10**6 live, nontransduced B16 cells
subcutaneously. Open circles, animal succumbed to tumor challenge;
filled circles, animal protected from tumor challenge. [ref: 68]