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Cancer - Principles & Practice of Oncology
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CHAP60
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F7.CAP
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1999-06-07
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386b
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FIGURE 60-7. Chimeric immunoglobulin T-cell receptor (TCR) combines
antibody variable regions with T-cell signaling chains. In this
diagram, a scFv fragment derived from the variable regions of a
monoclonal antibody is joined to the Fc receptor gamma chain, which is
related to the TCR-zeta chain and can mediate T-cell signal
transduction. [ref: 129]