ocr: Agent Action Clinical Use Leucovorin Repletes reduced intracellular folate stores For patients receiving high-dose methotrexate, pre- vents myelosuppression and mucositis Dexrazoxane Chelates iron Protects against anthracychine-induced cardiotoxicity Mesna Active monomer neutralizes cyclophosphamide- and Active only in bladder; prevents hemorrhagic cystitis meraptocthane-salionatc) fostamide-induced reactive species but not other toxicities Amifostine Scavenges free radicals Selectively attenuates toxicities from radiotherapy or Inactivates reactive species through tormation of thi- chemothera ...
