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Cancer - Principles & Practice of Oncology
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1999-06-07
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FIGURE 7-2. The origin of biological heterogeneity in primary
neoplasms and metastases. Biological heterogeneity in tumors that are
unicellular in origin is due to genetic and epigenetic instability. By
the time of diagnosis, most neoplasms consist of multiple
subpopulations of cells with different properties. Metastases can have
a clonal origin and different metastases can originate from different
progenitor cells. Even in clonal metastases, biologic diversification
gives rise to heterogeneous lesions.