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OCR: HTLV-I Infected T-Cell NUCLEUS HTLV-I Provirus Transcription Pathway Tax Activation NF. KE precursor binding; 3-polymerase bZIP protein dimerization Gene Expression: IL-2 IL-2R NF. xB GM-CSF IL-1 IL-3, IL-6 c-sis c-fos, vimentin, MHC- Class TNF-3 TGF- others IL-2 CYTOPLASM Chronic Polyclonal T-Cell Expansion T HOST CELL DNA REPAIR Second Transforming Event Oligoclonal or Monoclonal Proliferation Organ Infiltration Hypercalcemia Lymphadenopathy ATL Oppor tunistic infection dimorization H0ST Oliaoclonal