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Cancer - Principles & Practice of Oncology
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Oncology.iso
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CHAP8
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F2_2.CAP
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1999-06-07
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816b
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FIGURE 8.2-2. The genomic map of HPV-16 deduced from the DNA sequence.
The nucleotide numbers are noted within the circular maps,
transcription proceeds clockwise, and the major open reading frames
(E1 to E7, L1, and L2) are indicated. The only transcriptional
promoter mapped to data for HPV-16 is designated (P(97)). A(E) and
A(L) represent the putative polyadenylation signals for the early and
late transcripts, respectively. The viral long control region (LCR)
containing the putative viral transcriptional and replication
regulatory elements is noted. The closed circles on the genome
represent the four E2 binding sites that have been noted in the LCR.
The figure has been previously published and is reproduced with
permission. [ref: 157]