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Text File | 1995-05-16 | 3.9 KB | 126 lines | [TEXT/EDIT] |
- This is a new release of the TopPred II software which should substitute
- older versions. The essentials of this update are:
-
- Application TopPred II
- Version 1.2
- Update May 1995
- Authors M.G. Claros and G. von Heijne
- Description Prediction of transmembrane segments in integral
- membrane proteins, and the putative topologies, using
- several algorithms
- Literature CABIOS 10(6), 685-686 (1994)
-
- Notes 1- TopPred II is available as a "compatible" application, or as
- a "rapid" one. The rapid one needs 68020 processor, or later,
- and FPU.
-
- 2- A postcript file containing the orignal paper about this
- software can be found with the programs. It could be printed
- out with the LaserWriter Utility accompanying the apple printers,
- or the old Print PS application.
-
- 3- Three diferent algorithms are implemented to calculate transmembrane
- domains. The recommended is the described by Gunnar von Heijne in
- JMB 1992 (see the software on-line help), but it is also available
- the one of Patrick Argos in JMB 1994, and the one of F. Jähnig in
- TIBS 1990 for amphiphilic domains.
-
-
- TopPred II has been designed for Macintosh computers, using
- THINK Pascal 4.0.2. If someone is interested in making a version
- compatible with other platforms, he may contact me.
-
-
-
- TopPred II 1.2 (May 1995)
- =========================
-
- New features:
-
- # It has a new printed header
-
- # An algorithm for amphiphilic transmembrane domains has been included
- The corresponding modifications have been done in the on-line help.
-
- Bugs fixed:
-
- - All the scroll bars are active when they should.
-
- - The "Results" window updates are correct now.
-
- - Deleting the excess of text in the same window is not apparent.
-
- - Keyboard equivalents for the Edit menu do work now.
-
- - My fax number has been corrected (the former was my phone number)
-
-
-
- TopPred II 1.1.1 (April 1995)
- =============================
-
- Bugs fixed:
-
- - "Integer overflow" error when more than 32 Kb of text is written
- on the Results window will not occurs anymore.
-
- - Command-colon and ESC interruptions have been implemented
-
- - The text results were not always printable. They should be now.
-
- - When moving a TEXT file on the TopPred icon, the file is opened
- correctly.
-
-
- TopPred II 1.1 (January 1995)
- =============================
-
- TopPred II is now available in two different versions:
-
- § "TopPredII 1.1" which is "compatible" with any kind of macintosh
- computer.
-
- § "TopPredII 1.1 FPU" which is a "rapid" version of TopPred. This one
- needs a macintosh with a 68020 processor or later, containing an FPU.
- This version is significatively faster making profiles and
- constructing protein topologies (in several cases up to 6-fold
- faster)
-
-
- Other modifications:
-
- - "Open" has been substituted by "Load" in menus
-
- - Minor modifications have been operated in displaying results
- on screen.
-
- - FOS is no longer a TEXT file.
-
- - Previous versions hung when one searched for protein topologies
- without any transmembrane domain. This is fixed now.
-
- - Problems reading some sequence files have been fixed.
-
- - G. von Heijne address and the reference to the article about
- TopPred II have been updated in the on-line help.
-
- - Finally, some other minor details have been fixed, and several
- routines accelerated.
-
-
- Bugs not fixed:
-
- o Problems concerning the scroll bar of the text result
- window: it is only active when the graphic window is hidden.
-
- o When the Edit menu changes, keyboard equivalents do not work untill
- you open for the first time this menu in the new configuration.
-
- o When a TEXT file is moved on the TopPred icon, it opens but
- displays a lot of error messages since TopPred thinks that it is
- a FOS and not a sequence.
-
-
- Manuel G. Claros
- claros@biolgie.ens.fr
-