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OCR: HORMONE LEVELS T HERE ARE MARKED hormonal changes during pregnancy as extra quantities of the female sex hormones, estrogen and progesterone, are produced. Estrogen is commonly associated with a sense of well-being, while recent studies have shown progesterone to be associated with discomfort and typical premenstrual symptoms. Levels of the "male" hormone, free-ranging testosterone (which may be responsible for sex drive), fall slightly in pregnancy. Perhaps the most confusing thing about pregnancy is the way that moods can change. This is often due to changes in hormone balances.