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1996-01-30
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Document 0115
DOCN M9610115
TI Liver pathology in rural south-west Cameroon.
DT 9601
AU Skalsky JA; Joller-Jemelka HI; Bianchi L; Knoblauch M; Manyemen General
Hospital, Cameroon.
SO Trans R Soc Trop Med Hyg. 1995 Jul-Aug;89(4):411-4. Unique Identifier :
AIDSLINE MED/96014733
AB In a prospective study, 102 hospital patients with liver disease were
evaluated in West Cameroon, Africa. Blood donors, pregnant women and
patients without liver disease served as controls. A total of 757
individuals were tested for markers of hepatitis A, B, C and D and for
immunological markers (autoantibodies, procollagen III,
alpha-foetoprotein, CA50 antigen, alpha-1-antitrypsin and antibodies to
human immunodeficiency virus types 1 and 2). One-third of the liver
disease patients had focal lesions on ultrasound examination.
Histologically, 20 cases of cirrhosis, 14 cases of chronic hepatitis, 15
hepatocellular carcinomas and 17 cases of acute hepatitis were detected.
All hepatic patients and virtually all controls had had a previous
hepatitis A virus infection. Over 85% of adult patients and controls had
at least one marker of hepatitis B virus infection. Over 30% of patients
with liver disease had markers of possible hepatitis B virus
replication. Antihepatitis C virus antibody was present in 18% of
hepatic patients and in 6% of controls. Hepatitis C virus infection
seems to play an important role in the development of chronic liver
pathology; 40% of cirrhotic patients had a combined hepatitis B and C
virus infection. Serum autoantibodies were frequently found and were not
correlated with the presence of autoimmune liver disease.
DE Adolescence Adult Age Distribution Aged Aged, 80 and over
Biological Markers Cameroon/EPIDEMIOLOGY Child Child, Preschool
Female Health Status Hepatitis, Viral, Human/EPIDEMIOLOGY/VIROLOGY
Human Infant Liver Diseases/*EPIDEMIOLOGY/ETIOLOGY/IMMUNOLOGY Liver
Function Tests Male Middle Age Prospective Studies JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).