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M9610192.TXT
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1996-01-30
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Document 0192
DOCN M9610192
TI Taste and smell losses in HIV infected patients.
DT 9601
AU Graham CS; Graham BG; Bartlett JA; Heald AE; Schiffman SS; Department of
Psychiatry, Duke University Medical Center, Durham,; NC 27710, USA.
SO Physiol Behav. 1995 Aug;58(2):287-93. Unique Identifier : AIDSLINE
MED/96028651
AB Human immunodeficiency virus (HIV-1) associated wasting is an
increasingly common clinical manifestation of AIDS. The pathogenesis of
wasting is multifactorial and includes reduced caloric intake as a major
contributing mechanism. The perceptions of taste and smell play an
important role in stimulating caloric intake and in optimizing nutrient
absorption through cephalic phase reflexes. The purpose of this study
was to evaluate the degree of losses in taste and smell function that
occur in subjects infected with HIV. Taste and smell function was
evaluated in 40 HIV infected individuals and 40 healthy control subjects
matched for age, sex, race, smoking behavior, and number of years of
education. Chemosensory tests administered to subjects included taste
and smell detection thresholds, taste and smell memory tests, taste and
smell discrimination tests, and taste and smell identification tasks.
Significant differences were observed between experimental and control
subjects in glutamic acid taste detection threshold (p < 0.001), quinine
hydrochloride taste detection threshold (p < 0.001), menthol smell
detection threshold (p < 0.001) and in the taste identification task (p
= 0.006). Overall the results suggest abnormalities in the peripheral
and central nervous systems, and subjective distortion of taste and
smell. A significant correlation was not established between CDC
classification of HIV infection and taste and smell function, although
trends were observed suggesting worsening function with progression of
HIV disease. These results document significant taste and smell losses
in HIV infected subjects which may be of clinical significance in the
development or progression of HIV associated wasting.
DE Acquired Immunodeficiency Syndrome/DRUG THERAPY/*PHYSIOPATHOLOGY/
PSYCHOLOGY Adult Anosmia/*PHYSIOPATHOLOGY/PSYCHOLOGY Antiviral
Agents/ADVERSE EFFECTS/THERAPEUTIC USE Body Weight/PHYSIOLOGY
Cognition/PHYSIOLOGY Discrimination (Psychology)/PHYSIOLOGY Female
Human *HIV-1 Male Memory/PHYSIOLOGY Sensory Thresholds/PHYSIOLOGY
Smell/PHYSIOLOGY Smoking/PHYSIOPATHOLOGY/PSYCHOLOGY Taste
Disorders/*PHYSIOPATHOLOGY/PSYCHOLOGY Taste Threshold/PHYSIOLOGY
Zidovudine/ADVERSE EFFECTS/THERAPEUTIC USE CLINICAL TRIAL JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).