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1996-01-30
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Document 0300
DOCN M9610300
TI Human immunodeficiency virus-associated glomerulosclerosis.
DT 9601
AU Humphreys MH; San Francisco General Hospital, University of California
San; Francisco 94143, USA.
SO Kidney Int. 1995 Aug;48(2):311-20. Unique Identifier : AIDSLINE
MED/96047704
AB The constellation of nephrotic proteinuria, FSGS, and rapid loss of
renal function in a patient infected with HIV-1 has been sufficiently
widespread and well documented to justify identification as a specific
renal syndrome, HIV-associated nephropathy. The position paper of the
National Kidney Foundation-National Institutes of Health task force
estimated in 1990 that 10,000 to 15,000 persons will develop renal
disease in association with AIDS [94]. Management of these patients is
complex, and many will reach ESRD and require dialysis treatment, posing
additional care problems. Greater understanding of the pathogenesis of
the renal disease should lead to treatments which will forestall the
development of HIVAN and possibly other forms of fibrotic renal disease.
The ultimate eradication of AIDS will consign this renal syndrome to an
interesting footnote in the history of nephrology. Since that time is
still far in the future, nephrologists will continue to be faced with
the need to diagnose and treat HIV-1-infected patients with renal
involvement.
DE *AIDS-Associated Nephropathy/EPIDEMIOLOGY/PATHOLOGY/THERAPY Biopsy
*Glomerulosclerosis, Focal Human Kidney/PATHOLOGY Kidney Failure,
Chronic/THERAPY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).