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M9610314.TXT
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1996-01-30
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Document 0314
DOCN M9610314
TI Infection with hepatitis viruses (B and C) and human retroviruses
(HTLV-1 and HIV) in Saudi children receiving cycled cancer chemotherapy.
DT 9601
AU Bakir TM; Kurbaan KM; al Fawaz I; Ramia S; Department of Pathology,
College of Medicine, King Saud; University, Riyadh, Saudi Arabia.
SO J Trop Pediatr. 1995 Aug;41(4):206-9. Unique Identifier : AIDSLINE
MED/96054055
AB Serological markers of hepatitis B virus (HBV), hepatitis C virus (HCV),
human T-cell lymphotropic virus type 1 (HTLV-1), and human
immunodeficiency viruses (HIV-1 and HIV-2) were studied in 53 Saudi
children (31 males, 22 females; 1-12 years of age) receiving cycled
cancer chemotherapy and in 168 healthy Saudi children taken as control.
Exposure to HBV in the patients was similar to that in the control (6
per cent HBsAg in patients v. 7 per cent in the control; 19 per cent
exposure rate in patients v. 20 per cent in control). None of our
patients was vaccinated against HBV prior to chemotherapy. The fact that
among the 10 HBV exposed patients five patients were anti-HBs-positive
is in favour of vaccinating Saudi oncology patients against HBV prior to
chemotherapy. In contrast to the situation with HBV the prevalence of
anti-HCV in the patients (11 per cent) was significantly higher than
that in the control (1 per cent) (P = 0.003). None of our patients or
the control were anti-HTLV-1 or anti-HIV-positive. The results of this
study stress the need for an awareness of HCV problem in Saudi oncology
patients. Strict measures of screening blood donors for all blood-borne
viruses and, in particular, for HCV in addition to the use of disposable
equipment in management of cancer patients are items that should be
implemented as soon as possible.
DE Antineoplastic Agents, Combined/THERAPEUTIC USE Chi-Square Distribution
Child Child, Preschool Female Hepatitis
B/*COMPLICATIONS/DIAGNOSIS/EPIDEMIOLOGY Hepatitis
C/*COMPLICATIONS/DIAGNOSIS/EPIDEMIOLOGY Human HIV
Infections/*COMPLICATIONS/DIAGNOSIS/EPIDEMIOLOGY HTLV-I
Infections/*COMPLICATIONS/DIAGNOSIS/EPIDEMIOLOGY Infant Male
Neoplasms/*COMPLICATIONS/DRUG THERAPY/VIROLOGY Prevalence Risk Factors
Saudi Arabia/EPIDEMIOLOGY Serodiagnosis Seroepidemiologic Methods
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).