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1996-01-30
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Document 0347
DOCN M9610347
TI Treatment intensity and reduction in drug use for cocaine-dependent
methadone patients: a dose-response relationship.
DT 9601
AU Rosenblum A; Magura S; Foote J; Palij M; Handelsman L; Lovejoy M;
Stimmel B; National Development and Research Institutes, Inc., New York,
New; York 10013, USA.
SO J Psychoactive Drugs. 1995 Apr-Jun;27(2):151-9. Unique Identifier :
AIDSLINE MED/96053692
AB This study examined the impact of treatment intensity on cocaine use.
Seventy-seven cocaine-using methadone patients were enrolled in a
six-month, structured, manual-driven, cognitive-behavioral treatment
program. Sessions consisted of five individual and/or group sessions per
week. At intake subjects showed extensive polydrug abuse, psychiatric
comorbidity, criminal histories, and HIV risk behaviors. Treatment
intensity was measured by dividing number of sessions attended into
quartiles. Paired comparisons, within treatment quartiles, were made
between subjects' intake and six-month self-reports of cocaine use.
Subjects in quartiles two through four showed significant reductions in
frequency of cocaine use at follow-up, with subjects who received the
most treatment showing the greatest reductions in cocaine use. Bivariate
and multivariate analyses showed that treatment sessions attended
remained a strong predictor of reduction in cocaine use at follow-up,
even after controlling for drug use at intake and background variables.
The results indicate that there is a substantial treatment dose-response
relationship.
DE Adult *Cocaine Cognitive Therapy Dose-Response Relationship, Drug
Female Follow-Up Studies Human Male Methadone/ADMINISTRATION &
DOSAGE/*THERAPEUTIC USE Middle Age Multivariate Analysis New York
City Socioeconomic Factors Substance
Dependence/COMPLICATIONS/EPIDEMIOLOGY/*REHABILITATION Support, U.S.
Gov't, P.H.S. CLINICAL TRIAL JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).