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M9610387.TXT
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1996-01-30
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Document 0387
DOCN M9610387
TI Phenotypic and functional parameters of cellular immunity in a
chimpanzee with a naturally acquired simian immunodeficiency virus
infection.
DT 9601
AU Kestens L; Vingerhoets J; Peeters M; Vanham G; Vereecken C; Penne G;
Niphuis H; van Eerd P; van der Groen G; Gigase P; et al; Laboratory of
Pathology-Immunology, Institute of Tropical; Medicine, Antwerp, Belgium.
SO J Infect Dis. 1995 Oct;172(4):957-63. Unique Identifier : AIDSLINE
MED/96029361
AB The cellular immunologic and virologic status of a chimpanzee, naturally
infected with a human immunodeficiency virus type 1 (HIV-1)-like
lentivirus (SIVcpz-ant), was compared longitudinally with those of 3
HIV-1-infected and 5 uninfected chimpanzees for a period of 49 months.
Evidence of immune deficiency was not observed in the HIV-1-infected
chimpanzees, nor could virus be isolated from plasma. Virus could be
isolated from plasma of the SIVcpz-ant-infected chimpanzee, but clinical
signs of immune deficiency were never observed. Absolute CD4+ cell
counts remained relatively stable, but NK cells fluctuated significantly
over time and tended to correlate inversely with the virus titer in
peripheral blood. Although only CD8+ T cells were directly demonstrated
to exert a suppressive effect on viral replication in vitro, the
observed fluctuation of NK cells suggests that these cells may also be
involved in the interaction with lentivirus infection in this species.
DE Animal Animals, Laboratory Antigens, CD3 Chimpansee troglodytes
Cytotoxicity, Immunologic CD4-Positive T-Lymphocytes CD8-Positive
T-Lymphocytes Follow-Up Studies HIV-1/CLASSIFICATION *Immunity,
Cellular Killer Cells, Natural Leukocytes, Mononuclear/VIROLOGY
Lymphocyte Subsets Lymphocyte Transformation Male Simian Acquired
Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY/ *VETERINARY Support,
Non-U.S. Gov't SIV/CLASSIFICATION/GROWTH & DEVELOPMENT/IMMUNOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).