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1996-01-30
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Document 0460
DOCN M9610460
TI Temporal stability of acute stressor-induced changes in cellular
immunity.
DT 9601
AU Mills PJ; Haeri SL; Dimsdale JE; Department of Psychiatry, University of
California, San Diego, La; Jolla 92103-0804, USA.
SO Int J Psychophysiol. 1995 Apr;19(3):287-90. Unique Identifier : AIDSLINE
MED/96057785
AB This study examined the temporal stability of enumerative immune
responses to acute psychosocial stress. Lymphocyte subsets were measured
in 24 healthy male subjects at rest and following a speaking stressor on
two occasions approximately six weeks apart. The speaking task caused
significant increases in T-suppressor/cytotoxic cells, natural killer
cells, T-cells, and total WBC and decreases in the T-helper/suppressor
ratio. Baseline test-retest correlation's were statistically significant
for all variables (r values = 0.40-0.90). With two exceptions (T-cells
and T-suppressor/cytotoxic cells), speaking task values (absolute
reactivity scores) were also statistically significant (r values =
0.48-0.92). Baseline adjusted test-retest correlations were however
generally less reliable, with only natural killer cells (r values >
0.40), the T-helper/suppressor ratio (r = 0.60), and total WBC (r =
0.48) showing statistical significance. The findings suggest that
certain but not all cellular immune responses to acute stress are
moderately stable over time.
DE Adult CD4-CD8 Ratio Human Immunity, Cellular/*PHYSIOLOGY Killer
Cells, Natural/IMMUNOLOGY Leukocyte Count Lymphocyte Count Male
Stress, Psychological/*IMMUNOLOGY Support, U.S. Gov't, P.H.S.
T-Lymphocytes, Cytotoxic/IMMUNOLOGY T-Lymphocytes,
Helper-Inducer/IMMUNOLOGY Time Factors CLINICAL TRIAL JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).