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M9610517.TXT
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Document 0517
DOCN M9610517
TI Clinical utility of blood cultures in adult patients with
community-acquired pneumonia without defined underlying risks [see
comments]
DT 9601
AU Chalasani NP; Valdecanas MA; Gopal AK; McGowan JE Jr; Jurado RL;
Department of Medicine, Emory University School of Medicine,; Grady
Memorial Hospital, Atlanta, USA.
SO Chest. 1995 Oct;108(4):932-6. Unique Identifier : AIDSLINE MED/96010146
CM Comment in: Chest 1995 Oct;108(4):891-2
AB STUDY OBJECTIVE: We retrospectively examined the clinical utility of
obtaining routine blood cultures before the administration of
antibiotics in certain nonimmunosuppressed patients with
community-acquired pneumonia (CAP) admitted to the hospital during 1991.
DESIGN: Retrospective review. SETTING: Grady Memorial Hospital (a county
hospital primarily serving inner-city Atlanta). PATIENTS OR
PARTICIPANTS: Hospital discharge diagnosis listings identified 1,250
adults ( > or = 18 years old) with pneumonia. From this group of
patients, we selected patients admitted to the hospital with (1)
respiratory symptoms and a lobar infiltrate on chest radiograph that
were present at the time of hospital admission, (2) two or more sets of
blood cultures obtained within 48 h of hospital admission, and (3)
absence of defined risk factors: HIV-related illness, malignancy, recent
chemotherapy, steroid therapy, sickle cell disease, nursing home
residence, or hospital stays within the past 14 days. MEASUREMENTS AND
RESULTS: Five hundred seventeen patients (mean age, 52 years;: age
range, 18 to 103 years) qualified. Of these 517 patients, 25 patients
(4.8%) had growth in blood cultures considered contaminants while 34
(6.6%) had blood cultures positive for the following pathogens: 29
Streptococcus pneumoniae, 3 Haemophilus influenzae, and 1 Streptococcus
pyogenes, 1 Escherichia coli. Antibiotic therapy was changed for 7 of
the 34 patients with positive blood cultures (1.4% of study patients).
Antibiotic regimens were altered in 48 additional patients based on
sputum culture, poor clinical response, and allergic reactions.
CONCLUSIONS: Few blood cultures were positive for likely infecting
organisms in adult patients with CAP without defined underlying risk
factors. Furthermore, a total of $34,122 was spent on blood cultures at
$66 per patient. In this carefully defined group of patients, blood
cultures may have limited clinical utility and questionable
cost-effectiveness.
DE Adolescence Adult Aged Aged, 80 and over Bacteremia/*MICROBIOLOGY
Bacteria/ISOLATION & PURIF Community-Acquired Infections/MICROBIOLOGY
Comparative Study Female Georgia Hospitals, Public Human Male
Middle Age Pneumonia, Bacterial/*MICROBIOLOGY Retrospective Studies
Risk Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).