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1996-01-30
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Document 0574
DOCN M9610574
TI AIDS: clinical and scientific issues past, present and future.
DT 9601
AU Dalgleish AG; Moyle GJ; Easterbrook P; Gazzard BG; Division of Oncology,
St. George's Hospital Medical School,; London, U.K.
SO Q J Nucl Med. 1995 Sep;39(3):156-62. Unique Identifier : AIDSLINE
MED/96033585
AB The time from the recognition that AIDS was an infectious disease, to
the discovery of HIV as the causative agent and the identification of
the first specific antiviral agent that showed some clinical benefit,
was impressively short. Over the last few years it would appear that
progress against AIDS has slowed down considerably. Neither new
treatments nor vaccines have given much grounds for optimism and back to
basics has been the main battle cry. However it is easy to overlook the
tremendous improvements that have taken place in the management of HIV
disease in the absence of a curative treatment. Many of the
opportunistic infections that used to kill patients are not only
treatable but are able to be treated prophylactically. This has altered
the clinical spectrum of disease with many patients surviving several
years with virtually no CD4 lymphocytes only to succumb to other HIV
related disease such as non Hodgkins lymphoma. This review identifies
the major advances that have occurred in our understanding of AIDS and
identifies the major problems to be overcome in the next few years at
both the clinical and basic levels.
DE *Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/PREVENTION &
CONTROL/THERAPY Human JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).