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M9610657.TXT
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1996-01-30
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Document 0657
DOCN M9610657
TI Survival trends in adolescents with human immunodeficiency virus
infection.
DT 9601
AU Remafedi G; Lauer T; Department of Pediatrics, University of Minnesota
Hospital and; Clinics, Minneapolis, USA.
SO Arch Pediatr Adolesc Med. 1995 Oct;149(10):1093-6. Unique Identifier :
AIDSLINE MED/96003536
AB OBJECTIVE: To examine trends in survival and death in nonhemophiliac
adolescents with human immunodeficiency virus (HIV) infection. DESIGN:
Case series. SUBJECTS: All 117 HIV-seropositive adolescents (age range,
13 to 21 years) without hemophilia whose cases were reported through
December 1992. SETTING: A state with mandatory, name-linked reporting of
cases of HIV. METHODS: Review of death certificates and public records,
and interviews with subjects and key informants. ANALYSES: Kaplan-Meier
and Cox proportional hazards regression analyses of time from the
diagnosis of HIV infection to death. RESULTS: Documentation of death or
survival was available for 92% (108/117) of the sample. Fourteen percent
(15/108) of the subjects were known to have died, mainly of
well-recognized complications of acquired immunodeficiency syndrome.
Among deceased subjects, the median duration of survival after the
diagnosis of HIV was 3 years. Cumulative survival at 8 years after the
diagnosis was 52%, with 4 years being the median period of observation
(range, < 1 year to 8 years). Stratification of survival functions by
gender, race, and mode of transmission revealed no significant (P < .05)
differences between groups. However, advancing age at the time of the
diagnosis was inversely associated with survival. CONCLUSIONS: Despite
an apparent advantage to young age, overall survival in this adolescent
cohort was shorter than expected. Rather than an inherently rapid
progression of disease during adolescence, delays in diagnosis and
treatment might better explain the results.
DE Adolescence Adult Age Factors Cause of Death Disease Notification
Female Human HIV Seropositivity/*MORTALITY Male Medical Record
Linkage Minnesota/EPIDEMIOLOGY Population Surveillance Proportional
Hazards Models Support, U.S. Gov't, P.H.S. Survival Analysis Survival
Rate/TRENDS Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).