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M9610696.TXT
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1996-01-30
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Document 0696
DOCN M9610696
TI [Alpha tumor necrosis factor in central nervous system disease
associated with HIV infection]
DT 9601
AU Calvo Manuel E; Arranz Garcia F; Sanchez-Portocarrero J; Roca Arbones V;
Puente M; Elias Arcalis A; Perez-Cecilia E; Nieto Sanchez A; Espinos
Perez D; Servicio de Medicina Interna I, Hospital Universitario San;
Carlos, Facultad de Medicina, Universidad Complutense, Madrid.
SO An Med Interna. 1995 Jun;12(6):263-6. Unique Identifier : AIDSLINE
MED/96005176
AB The aim of the present study is to evaluate the relationship between the
alpha tumor necrosis factor (TNF-alpha), interleukin 1 beta (IL-1 beta)
and the neurological disease associated to the HIV-1 infection and
different neurological manifestations (15 infections of the CNS and 11
AIDS-dementia complexes) and 14 from a control group. The mean value of
TNF-alpha in CSF of patients with HIV-1 infection and AIDS-dementia
complex was 19.8 +/- 30.6 pg/ml, superior to that of the control group
(p < 0.05). The group of patients with HIV-1 and opportunistic CNS
infection has a TNF-alpha value of 28.5 +/- 37.8 pg/ml, that is superior
to that of the patients with the AIDS-dementia complex (TNF-alpha = 7.9
+/- 9.4 pg ml; p < 0.05). Within the group of patients with a CNS
infection, the value of TNF-alpha was greater in those in the acute
phase (44.2 +/- 42.4 pg/ml) than in those in the chronic phase (6.8 +/-
7.6 pg/ml; p < 0.05). The TNF-alpha in the CSF is a good marker of
infection of the CNS in the HIV-1 infection.
DE Acquired Immunodeficiency Syndrome/CEREBROSPINAL FLUID/
COMPLICATIONS/*DIAGNOSIS AIDS Dementia Complex/*CEREBROSPINAL
FLUID/DIAGNOSIS Biological Markers Central Nervous System
Diseases/CEREBROSPINAL FLUID/*DIAGNOSIS/ ETIOLOGY Comparative Study
Data Interpretation, Statistical English Abstract Enzyme-Linked
Immunosorbent Assay Human HIV-1 Interleukin-1/BLOOD Tumor Necrosis
Factor/*CEREBROSPINAL FLUID JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).