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1996-01-30
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Document 0814
DOCN M9610814
TI Magnetic resonance spectroscopy in childhood AIDS encephalopathy.
DT 9601
AU Pavlakis SG; Lu D; Frank Y; Bakshi S; Pahwa S; Barnett TA; Porricolo ME;
Gould RJ; Nozyce ML; Hyman RA; Department of Radiology, North Shore
University Hospital,; Manhasset, New York, USA.
SO Pediatr Neurol. 1995 May;12(4):277-82. Unique Identifier : AIDSLINE
MED/96044396
AB Twenty-five children with acquired immunodeficiency syndrome (AIDS)
underwent cranial magnetic resonance imaging and proton magnetic
resonance spectroscopy. Patients were divided into 2 groups based on
clinical parameters: encephalopathy and nonencephalopathy. N-acetyl
aspartate/creatine ratios were compared between the 2 groups and to
control data. Spectra were obtained for 2 volumes of interest: the basal
ganglia region and the white matter. The mean basal ganglia region ratio
for the AIDS encephalopathy patients (n = 8) was 1.12 and the ratio for
the AIDS nonencephalopathy patients (n = 17) was 1.48. The ratio for the
9 controls was 1.57. The encephalopathy group had a significantly lower
ratio than both the control (P < .001) and the AIDS nonencephalopathy
group (P < .002). The mean white matter ratio for the encephalopathy
group (n = 8) was 1.47 and for the AIDS nonencephalopathy group (n = 13)
was 1.82 with a control (n = 6) ratio of 1.82. The encephalopathy
patients had a lower white matter ratio than the nonencephalopathy (P <
.05) patients but the ratio was not different than controls (P < .11).
It is concluded that N-acetyl aspartate/creatine ratios are reduced in
childhood AIDS encephalopathy and proton magnetic resonance spectroscopy
may be helpful in defining brain human immunodeficiency virus-1
infection. However, further longitudinal studies are necessary to
determine the sensitivity and specificity of this technique.
DE Adolescence AIDS Dementia Complex/*DIAGNOSIS Basal Ganglia/*PATHOLOGY
Case-Control Studies Child Child, Preschool Human Infant Magnetic
Resonance Imaging *Nuclear Magnetic Resonance Protons Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).