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1996-02-26
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Document 0001
DOCN M9620001
TI A reexamination of the relationship between active rheumatoid arthritis
and the acquired immunodeficiency syndrome.
DT 9602
AU Ornstein MH; Kerr LD; Spiera H; Mount Sinai Medical Center, New York,
New York 10029-6574, USA.
SO Arthritis Rheum. 1995 Nov;38(11):1701-6. Unique Identifier : AIDSLINE
MED/96062446
AB Three patients with rheumatoid arthritis (RA) that remitted with the
development of the human immunodeficiency virus (HIV) infection have
been described in the literature, and this has contributed to the belief
that RA and HIV infection or the acquired immunodeficiency syndrome
(AIDS) cannot coexist. However, a computerized MEDLINE literature search
revealed reports of 4 patients who did have active RA and AIDS or HIV
infection, as well as other case reports of symmetric polyarthritis
compatible with RA in patients with HIV infection. Each of the patients
whose RA remitted had received standard disease-modifying antirheumatic
drug therapy, and 1 of the 3 had a normal T helper:T suppressor ratio at
the time of remission. Of the 4 previously reported patients with active
RA and AIDS or HIV infection, all had decreased numbers of T helper
lymphocytes. The present report describes a fifth patient with both RA
and AIDS and reviews the data concerning the coexistence of these 2
diseases. It appears that active RA may indeed coexist with AIDS. It
remains to be seen under what settings HIV may have a disease-modifying
effect in RA. These issues have important implications regarding the
pathogenesis and therapy of RA, especially in terms of the role of CD4+
lymphocytes and anti-CD4 monoclonal antibody therapy.
DE Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS/PATHOLOGY Adult
Arthritis, Rheumatoid/BLOOD/*COMPLICATIONS/PATHOLOGY Case Report
CD4-CD8 Ratio CD4-Positive T-Lymphocytes/CYTOLOGY Female Human
Lymphocyte Count Male Middle Age JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).