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1996-02-26
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Document 0068
DOCN M9620068
TI Vortex keratopathy associated with atovaquone.
DT 9602
AU Shah GK; Cantrill HL; Holland EJ; Department of Ophthalmology,
University of Minnesota Hospital and; Clinics, USA.
SO Am J Ophthalmol. 1995 Nov;120(5):669-71. Unique Identifier : AIDSLINE
MED/96065059
AB PURPOSE: We studied a case of vortex keratopathy that was associated
with the use of atovaquone. METHOD: A patient with acquired
immunodeficiency syndrome (AIDS) with pulmonary Pneumocystis carinii was
treated with 750 mg of atovaquone three times a day. RESULTS: Similar to
previous findings of drug-induced vortex keratopathy, atovaquone vortex
keratopathy is presumably caused by its lipophilic properties. This
property is similar to that of other lipophilic agents such as
amiodarone, chloroquine, chlorpromazine, quinacrine, and suramin.
CONCLUSION: Atovaquone should be added to the list of agents causing
vortex keratopathy involving the corneal epithelium.
DE Antifungal Agents/*ADVERSE EFFECTS/THERAPEUTIC USE AIDS-Related
Opportunistic Infections/DRUG THERAPY Case Report Cornea/*DRUG
EFFECTS/PATHOLOGY Corneal Diseases/*CHEMICALLY INDUCED/PATHOLOGY
Epithelium/DRUG EFFECTS/PATHOLOGY Human Male Middle Age
Naphthoquinones/*ADVERSE EFFECTS/THERAPEUTIC USE Pneumonia,
Pneumocystis carinii/DRUG THERAPY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).