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- Document 0074
- DOCN M9620074
- TI Risk factors and cofactors for human T-cell lymphotropic virus type I
- (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in
- Jamaica.
- DT 9602
- AU Kramer A; Maloney EM; Morgan OS; Rodgers-Johnson P; Manns A; Murphy EL;
- Larsen S; Cranston B; Murphy J; Benichou J; et al; Viral Epidemiology
- Branch, National Cancer Institute, National; Institutes of Health,
- Rockville, MD, USA.
- SO Am J Epidemiol. 1995 Dec 1;142(11):1212-20. Unique Identifier : AIDSLINE
- MED/96071716
- AB Human T-cell lymphotropic virus type I (HTLV-I) has been etiologically
- associated with a neurologic syndrome called HTLV-I-associated
- myelopathy/tropical spastic paraparesis (HAM/TSP) as well as with adult
- T-cell leukemia/lymphoma. The authors sought to quantify the risk in
- Jamaica of HAM/TSP associated with HTLV-I infection and cofactors
- associated with this disease among infected individuals. Between 1988
- and 1989, prevalent and incident HAM/TSP patients and controls with
- other neurologic diseases were enrolled in a retrospective study. A
- second control group was composed of HTLV-I-seropositive, asymptomatic
- carriers in Jamaica, ascertained in a separate study conducted in 1988.
- Although HTLV-I seropositivity was not a component of the case
- definition for HAM/TSP, all 43 HAM/TSP patients were HTLV-I seropositive
- compared with two (4.0%) of the controls with other neurologic diseases.
- Given HTLV-I seropositivity, one cofactor associated with the risk of
- HAM/TSP was young age at initial heterosexual confidence interval
- 1.29-12.46 for individuals aged < or = 15; odds ratio = 4.26, 95%
- confidence interval 1.41-12.90 for individuals aged 16-17 years at
- initial intercourse). Among individuals who reported this early age at
- initial sexual intercourse, an increased risk of HAM/TSP was associated
- with having reported more than five lifetime sexual partners (odds ratio
- = 2.88, 95% confidence interval 0.90-8.70). Neither an early age at
- initial sexual intercourse or the number of lifetime sexual partners was
- a risk factor for adult T-cell leukemia/lymphoma. These data support the
- hypothesis that HAM/TSP is associated with sexually acquired HTLV-I
- infection, whereas adult T-cell leukemia/lymphoma is not.
- DE Adolescence Adult Age Factors Aged Comparative Study Female Human
- Jamaica/EPIDEMIOLOGY Leukemia-Lymphoma, T-Cell, Acute,
- HTLV-I-Associated/EPIDEMIOLOGY Logistic Models Male Middle Age
- Paraparesis, Tropical Spastic/*EPIDEMIOLOGY/IMMUNOLOGY/ TRANSMISSION
- Retrospective Studies Risk Factors Serodiagnosis Sex Behavior
- Sexually Transmitted Diseases, Viral/*EPIDEMIOLOGY/IMMUNOLOGY Support,
- U.S. Gov't, P.H.S. JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
-
-