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1996-02-26
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Document 0078
DOCN M9620078
TI Prospective evaluation of oropharyngeal findings in human
immunodeficiency virus-infected patients with esophageal ulceration [see
comments]
DT 9602
AU Wilcox CM; Straub RF; Clark WS; Department of Medicine, Emory University
School of Medicine,; Georgia, USA.
SO Am J Gastroenterol. 1995 Nov;90(11):1938-41. Unique Identifier :
AIDSLINE MED/96048743
CM Comment in: Am J Gastroenterol 1995 Nov;90(11):1914-5
AB OBJECTIVE: Although the presence of oropharyngeal (OP) candidiasis plays
an important role in the evaluation of human immunodeficiency virus
(HIV)-infected patients with esophageal symptoms, there is little
information on the utility of OP findings in patients with esophageal
ulceration. METHODS: Over a 54-month period, all HIV-infected patients
with esophageal ulceration had careful inspection of the oropharynx at
the time of presentation with esophageal complaints and at endoscopy.
HIV-infected patients without esophageal ulceration undergoing endoscopy
during the last 30 months had OP findings similarly documented. OP
ulceration ulceration was determined based on clinical, endoscopic, and
histopathological findings. RESULTS: Of the 124 patients identified with
esophageal ulcer, 14 (11%) had coexistent OP ulceration: herpes simplex
virus, four; idiopathic esophageal ulcer, four; cytomegalovirus, three;
herpes simplex virus and cytomegalovirus, two; idiopathic and
cytomegalovirus, one. Four patients had OP ulcer without esophageal
ulcer; only one of these patients had esophageal symptoms. All OP
lesions healed with therapy for the esophageal ulcer. Twenty-eight
patients with esophageal ulcer had OP candidiasis (23%); 21 of these
patients (75%) also had Candida esophagitis. The sensitivity and
specificity of OP ulcer for esophageal ulcer were 11% and 97%,
respectively. The positive and negative predictive values of OP
candidiasis for esophageal candidiasis were 90% and 82%, respectively.
CONCLUSIONS: OP ulceration is uncommon in patients with esophageal
ulceration, with the exception of herpes simplex virus esophagitis. OP
candidiasis is common in patients with underlying esophageal ulcer,
potentially resulting in diagnostic confusion. OP candidiasis appears to
be a moderately useful diagnostic marker for Candida esophagitis.
DE AIDS-Related Opportunistic Infections/*DIAGNOSIS/EPIDEMIOLOGY/
MICROBIOLOGY Candidiasis/*DIAGNOSIS/EPIDEMIOLOGY Candidiasis,
Oral/*DIAGNOSIS/EPIDEMIOLOGY Cytomegalovirus
Infections/DIAGNOSIS/EPIDEMIOLOGY Esophageal
Diseases/DIAGNOSIS/EPIDEMIOLOGY/*MICROBIOLOGY Esophagoscopy Herpes
Simplex/DIAGNOSIS/EPIDEMIOLOGY Human Oropharynx/MICROBIOLOGY/PATHOLOGY
Pharyngeal Diseases/DIAGNOSIS/EPIDEMIOLOGY/MICROBIOLOGY Predictive
Value of Tests Prevalence Prospective Studies Sensitivity and
Specificity Ulcer/DIAGNOSIS/EPIDEMIOLOGY/MICROBIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).