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1996-02-26
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Document 0128
DOCN M9620128
TI [Kaposi sarcoma. An epidemiological perspective]
DT 9602
AU Lecker S; Melbye M; Center for epidemiologisk grundforskning, Statens
Seruminstitut,; Kobenhavn.
SO Ugeskr Laeger. 1995 Sep 18;157(38):5232-6. Unique Identifier : AIDSLINE
MED/96075142
AB Prior to the 1980s, Kaposi's sarcoma was a rare tumour diagnosed three
to four times more frequently among men than women. It was primarily
seen among elderly men of Mediterranean or Jewish descent, in
well-defined areas of Central Africa, or more scattered as individual
cases with underlying immunosuppression. Geographical restrictions and
suggested associations with certain HLA-types gave rise to early
speculations of a genetic component involved in its etiology. With the
AIDS epidemic, the epidemiology of Kaposi's sarcoma changed drastically.
Although diagnosed among AIDS patients that are transfusion recipients,
intravenous drug users and haemophiliacs, Kaposi's sarcoma is primarily
found in homosexual men with AIDS among whom the risk has increased to
100,000 compared to the general population. Specific behaviours linked
to homosexual men have been sought to explain this relationship, but
accumulating evidence favours the involvement of an infectious agent in
the etiology of Kaposi's sarcoma. The most promising candidate today is
a possible new herpesvirus, similar to but distinct from Herpes-virus
saimiri and Epstein-Barr virus.
DE Africa/EPIDEMIOLOGY AIDS-Related Opportunistic Infections Bisexuality
English Abstract Europe/EPIDEMIOLOGY Female Homosexuality, Male
Human Immunocompromised Host Male Sarcoma,
Kaposi's/*EPIDEMIOLOGY/ETIOLOGY/VIROLOGY *World Health JOURNAL ARTICLE
REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).