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1996-02-26
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Document 0132
DOCN M9620132
TI The relationship between the flamenco gene and gypsy in Drosophila: how
to tame a retrovirus.
DT 9602
AU Bucheton A; Centre de Genetique Moleculaire, CNRS, Gif-sur-Yvette,
France.
SO Trends Genet. 1995 Sep;11(9):349-53. Unique Identifier : AIDSLINE
MED/96005621
AB For a long time, retroviruses have been considered to be restricted to
vertebrates. However, the genome of insects contains elements like gypsy
in Drosophila melanogaster that are strikingly similar to vertebrate
proviruses of retroviruses, which were considered to be transposable
elements. Recent results indicate that gypsy has infective properties
and is therefore a retrovirus, the first to be identified in
invertebrates. It is normally repressed by a host gene called flamenco,
which apparently controls the transposition and infective properties of
gypsy. This provides an exceptional experimental model to investigate
the genetic relationships between retroviruses and their hosts.
DE Alleles Animal Drosophila melanogaster/*GENETICS/*VIROLOGY
DNA-Binding Proteins/GENETICS Female Gene Expression Regulation, Viral
Genes, env *Genes, Structural, Insect Invertebrates/VIROLOGY Male
Organ Specificity Ovary/CYTOLOGY/VIROLOGY Repetitive Sequences,
Nucleic Acid *Retrotransposons Retroviridae/GENETICS/*ISOLATION &
PURIF/PHYSIOLOGY Support, Non-U.S. Gov't Transcription
Factors/GENETICS/*PHYSIOLOGY Virus Activation JOURNAL ARTICLE REVIEW
REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).